Well I think we’ve found the solution. Sell the Roland 
But just to be super duper clear - everything’s set up normal, you turn everything on EXCEPT the Roland (it’s plugged into the outlet but not powered on), and it’s noisy? If so, what happens if you unplug it from power? Still noisy?
You turn everything on, including the Roland, it’s noisy, you unplug the audio cables from the Roland and everything’s fine? Does that include the USB from PC to UCX, or is the USB stuff a different issue altogether unaffected by the Roland noise?
Also, is it both cables from the Roland or just one? Do they contribute equally to the noise? Just trying to get my head around what it might be doing.
That’s a good assumption. Computer PSUs, specifically the 5v rail, are dirty. Filthy. Very little filtering. Because why spend the money? Your mouse and keyboard don’t care. But it’ll wreak havoc with audio, especially when whatever it’s feeding have a common data/audio ground plane. ie all that noise comes in the data/power ground, mixes around and then goes out the audio ground. You can buy USB isolators that will decouple the connection, or you can go 100% ghetto and put black electrical tape over the power pins on the USB-A side so you’re only feeding data. That works but can sometimes mess with device recognition. It doesn’t hurt anything, your PC just won’t see the device until you uncover the pins. You could also try different USB cables, specifically one with a big ferrite bead.
That’s fucked up and terrifying and nowhere near code, but you make due with what you have. Assuming that’s indeed the case, you have a floating ground, as in “ground” is just the lowest voltage in that morass of equipment, and changes with different conditions and load levels. It’s not inherently bad - like a car is a floating ground, completely isolated from Earth and only tied to the chassis, but all the electrical systems are engineered around that idea, just like all your AC audio equipment is based around the idea of having a third prong connected to something. If all of your equipment was internally grounded/two-prong, none of this would likely be an issue, but you have a room full of stuff that’s assuming there’s a common earth ground at the end of the plug and there’s not. It’s also possible that’s why you see such a benefit from the DIs you’re using. I’m not ready to call this “The Issue” yet because it really seems like something with the Roland is the problem, but it’s certainly neither standard nor optimal.
These would be good things to check. If you have a loop somewhere acting as an antenna literally any source of EM can cause noise (fridge compressor kicking on, TV, radio tower, etc etc).
Troubleshooting this stuff is really process of elimination to see what contributes and what you can likely ignore while you zero in on the problem.