Sometimes, yes, but it depends on synths, MPE controllers and instruments. For some stuff (such as SWAM), you even have presets for LinnStrument and Seaboard and other controllers, for others MPE doesn’t work at all (also in many DAWs), so you can only use monophonic expression. It’s not always plug-n-play. But that also means it’s very flexible and you can assign whatever you want if you have a good synth and/or DAW (for instance, Bitwig is good with MPE, Live is still not useful for this at all - meaning you have to build racks with multiple instances to use synths in a pseudo-MPE way or you just use monophonic expression, meaning sticking to playing one note at a time 
)! Just yesterday I started a MPE thread you can also check out: Fav synths and VIs for playing with MPE instruments - #11 by metaside