I had a very frustrating weekend trying to get things to work, and failed.
I got the Interface and cable on Friday, and connected the Interface via USB to my computer, and then plugged the cable into the guitar and the interface's line 1 input. Tried a bunch of settings in my DAW, couldn't seem to get it to work at all.
Finally figured out that I needed a driver for the Audio Interface.
I went to the official site, which pointed me to the ASIO4All driver. I installed that, and then fiddled with settings some more in my DAW, which could now see "ASIO4All USB device."
Still nothing worked.
I finally found on the official site's forums a thread talking about how the ASIO4All driver didn't work on Windows 10 with their Audio Interface, and found a link to another driver that people were saying did the right thing.
Installed that driver, uninstalled the ASIO4All driver. Now my DAW can see the Audio Interface down to the model number. Should be good, right? Nope. Plucking on the guitar after arming an audio track still generated no sound. Turned on the in DAW monitor, was still getting nothing. Went to plug some headphones into the Audio Interface built-in monitor and realized it only accepts the larger form factor (I don't know the official terms for this) not my smaller headphone plug in. Couldn't monitor out of the Audio Interface to see if it's getting sound or not.
Am I missing something obvious here? I have never played an electric guitar before, I've never hooked one up to an Audio Interface, nor have I ever owned an Audio Interface before. I ended up getting too frustrated and quitting and didn't circle back to it yet.
Sounds like you're almost there. What DAW? Might need to set your input source on a specific track to be your interface's line input.
Finally figured it out after talking to the guy at Sweetwater - I needed to plug the guitar cord into the Instrument 2 plug-in instead of the the Mic/Line1. Once I got that going and turned up the output/gain enough it was working just fine.